When 15-year-old Kino is feeling weighed down by heavy thoughts, one thing always manages to cheer her up: traveling. Nothing fills her heart with joy like exploring the beautiful, wonderful world around her and the fascinating ways people find to live. However, Kino is not as helpless as her cute appearance and courteous demeanor suggest. Armed with "Cannon" and "Woodsman," her trusted handguns, Kino isn’t afraid to kill anyone who would dare to get in her way. Always by her side is her best friend and loyal companion Hermes, a sentient motorcycle, who supports Kino through the sorrows and hardships of their journey. Together, they travel the vast countryside with the shared goal of always moving forward, and a single rule: never stay in one country for more than three days.
As Kino and Hermes encounter new people and learn the rules of their civilizations, they grow and find out more about their own values and virtues. But as Kino slowly discovers the world around her, she also finds herself facing dangers that linger within the vast unknown.